Dr. Vivek. H. K
July 8, 2024 2024-07-24 20:07Dr. Vivek. H. K
Educational Qualifications
ongoing projects
Areas of research
Publications
Awards
Educational Qualifications
M.Sc: Biochemistry,
University of Mysore, Mysuru
Ph.D: Biotechnology,
Visvesvaraya Technological University, Belagavi
[Research Centre- Sri Jayachamarajendra College of Engineering,
(SJCE, Mysuru)]
ongoing projects
Sl. No. |
Name of PI and Co-PI |
Award No. |
Project Title |
Project Type/Funding agency |
Sanctioned Amount (Rs. in lakhs) |
| 1 | Byrappa,K,(PI) Prashantha, K (Co-PI) Babu A. Manjasetty (Co-PI), Vivek H.K |
CSB-31/2(MYS-NP)/2020-21/RCS |
Value addition of Cellulose and Chitin from Sericulture Waste for Advanced Packaging applications |
Central Silk Board (CSB), Ministry of Textiles, Government of India | ₹.25,54,360/- |
| 2 | Vivek HK (PI), Dinesha R, Pandareesh MD and Girish YR | ACU/R&D |
Nanoencapsulation of Turmein from Curcuma longa L: Preparation, Characterization and its implication for Cancer Therapy | ACU | ₹4,00,000/- |
Areas of research
Current Research Interests:
- My research mainly focuses on the Development of Bioassay, Analytical Method Validation, and also work in arears of Medicinal Chemistry to identify potent Bioactive using Computational tools targeting various inflammatory proteins
- Isolating a phytochemical targeting inflammatory diseases
- Study of Plant Proteomics
Publications
- Verma R, Verma S, K Hamse V, et al. Regioselective Synthesis, Antiproliferative Effect and Molecular Docking Studies of 2,3,5-Tri(Het)Aryl-Pyrrole Derivatives as a New Inhibitor of JAK3, VEGFR and PARP. Elsevier BV; 2023.
- Chowdary B． N, Preetham HD, Verma SK, et al. A short hydrophobic peptide conjugated 3,5- disubstituted pyrazoles as antibacterial agents with DNA gyrase inhibition. Journal of Molecular Structure. 2023;1276:134661.10.1016/j.molstruc.2022.134661
- M PH, Al-Ostoot FH, Vivek HK, Khanum SA. Synthesis, characterization, DFT, docking studies and molecular dynamics of some 3-phenyl-5-furan isoxazole derivatives as anti-inflammatory and anti-ulcer agents. Journal of Molecular Structure. 2022;1250:131812.10.1016/j.molstruc.2021.131812
- Girish YR, Kumar BMA, Kumar KSS, et al. Identification of novel benzimidazole-based small molecule targeting dual targets Tankyrase and Bcl2 to induce apoptosis in Colon cancer. Journal of Molecular Structure. 2022;1269:133813.10.1016/j.molstruc.2022.133813
- Vagish CB, Kumara K, Vivek HK, Bharath S, Lokanath NK, Ajay Kumar K. Coumarin-triazole hybrids: Design, microwave-assisted synthesis, crystal and molecular structure, theoretical and computational studies and screening for their anticancer potentials against PC-3 and DU-145. Journal of Molecular Structure. 2021;1230:129899.10.1016/j.molstruc.2021.129899
- Vidya V, Achar RR, Himathi MU, et al. Venom peptides – A comprehensive translational perspective in pain management. Curr Res Toxicol. 2021;2:329-340.10.1016/j.crtox.2021.09.001
- Suryakoppa KS, Kameshwar VH, Appadurai R, Eranna S, Khan MHM. Enantiomeric Separation of Indole-3-Propanamide Derivatives by Using Supercritical Fluid Chromatography on a Polysaccharide-Based Chiral Stationary Phase. Journal of Chromatographic Science. 2021;60(7):692-704.10.1093/chromsci/bmab102
- Shwetha B, Sudhanva MS, Jagadeesha GS, et al. Furan-2-carboxamide derivative, a novel microtubule stabilizing agent induces mitotic arrest and potentiates apoptosis in cancer cells. Bioorganic Chemistry. 2021;108:104586.10.1016/j.bioorg.2020.104586
- Shreevatsa B, Dharmashekara C, Swamy VH, et al. Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy. Molecules. 2021;26(22):6863.10.3390/molecules26226863
- Radhika R, Ramadas D, Ragavan B, Sudarsanam D, Kameshwar VH. Acute Toxicological and Histopathological Elucidation of Rheum emodi Rhizome Extract to Demonstrate Antidiabetic Activity in Alloxan-induced Diabetic Rats. Current Bioactive Compounds. 2021;17(2):174-186.10.2174/1573407216666200330114306
- Pandareesh MD, Kameshwar VH, Byrappa K. Prostate Carcinogenesis: Insights in Relation to Epigenetics and Inflammation. Endocrine, Metabolic & Immune Disorders – Drug Targets. 2021;21(2):253-267.10.2174/1871530320666200719020709
- Kumara K, Prabhudeva MG, Vagish CB, et al. Design, synthesis, characterization, and antioxidant activity studies of novel thienyl-pyrazoles. Heliyon. 2021;7(7):e07592-e07592.10.1016/j.heliyon.2021.e07592
- Kumar AD, Vivek HK, Srinivasan B, et al. Design, synthesis, characterization, crystal structure, Hirshfeld surface analysis, DFT calculations, anticancer, angiogenic properties of new pyrazole carboxamide derivatives. Journal of Molecular Structure. 2021;1235:130271.10.1016/j.molstruc.2021.130271
- Al-Ostoot FH, Zabiulla, Grisha S, Mohammed YHE, Vivek HK, Ara Khanum S. Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies. Bioorganic & Medicinal Chemistry Letters. 2021;33:127743.10.1016/j.bmcl.2020.127743
- Al-Ostoot FH, Sherapura A, V V, et al. Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression. Pharmacological Reports. 2021;73(5):1328-1343.10.1007/s43440-021-00266-8.
- Vagish CB, Dileep Kumar A, Kumara K, et al. Environmentally benign synthesis of substituted pyrazoles as potent antioxidant agents, characterization and docking studies. Journal of the Iranian Chemical Society. 2020;18(2):479-493.10.1007/s13738-020-02042-6
- Sridhara MB, Rakesh KP, Manukumar HM, et al. Synthesis of Dihydrazones as Potential Anticancer and DNA Binding Candidates: A Validation by Molecular Docking Studies. Anti-Cancer Agents in Medicinal Chemistry. 2020;20(7):845-858.10.2174/1871520620666200225104558
- Prabhu Kumar KM, Vasantha Kumar BC, Kumar PR, et al. Synthesis, characterization, CT‐DNA binding and docking studies of novel selenated ligands and their palladium complexes. Applied Organometallic Chemistry. 2020;34(6).10.1002/aoc.5634
- Neema KN, Hamse Kameshwar V, Nafeesa Z, et al. Serine protease from Indian Cobra venom: its anticoagulant property and effect on human fibrinogen. Toxin Reviews. 2020;41(1):165-174.10.1080/15569543.2020.1855656
- Kumar D, Hamse VK, Neema KN, Babu Shubha P, Chetan DM, Shivananju NS. Purification and biochemical characterization of a novel secretory dipeptidyl peptidase IV from porcine serum. Molecular and Cellular Biochemistry. 2020;471(1-2):71-80.10.1007/s11010-020-03766-y
- Divya K, Vivek HK, Priya BS, Nanjunda Swamy S. Rapid detection of DPP-IV activity in porcine serum: A fluorospectrometric assay. Analytical Biochemistry. 2020;592:113557.10.1016/j.ab.2019.113557
- Channa Basappa V, Hamse Kameshwar V, Kumara K, Achutha DK, Neratur Krishnappagowda L, Kariyappa AK. Design and synthesis of coumarin-triazole hybrids: biocompatible anti-diabetic agents, in silico molecular docking and ADME screening. Heliyon. 2020;6(10):e05290-e05290.10.1016/j.heliyon.2020.e05290
- Zha G-F, Wang S-M, Rakesh KP, et al. Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections. European Journal of Medicinal Chemistry. 2019;162:364-377.10.1016/j.ejmech.2018.11.012
- Savitha MN, Siddesha JM, Suvilesh KN, et al. Active-site directed peptide l-Phe-d-His-l-Leu inhibits angiotensin converting enzyme activity and dexamethasone-induced hypertension in rats. Peptides. 2019;112:34-42.10.1016/j.peptides.2018.11.002
- Rakesh KP, Darshini N, Manukumar HM, et al. Xanthone Conjugated Amino Acids as Potential Anticancer and DNA Binding Agents: Molecular Docking, Cytotoxicity and SAR Studies. Anti-Cancer Agents in Medicinal Chemistry. 2019;18(15):2169-2177.10.2174/1871520618666180903105256
- Prabhudeva MG, Vivek HK, Kumar KA. Synthesis of novel pyrazole carboxamides using reusable catalyst as antimicrobial agents and molecular docking studies. Chemical Data Collections. 2019;20:100193.10.1016/j.cdc.2019.100193
- Jiang Y, Rakesh KP, Alharbi NS, et al. Radical scavenging and anti-inflammatory activities of (hetero)arylethenesulfonyl fluorides: Synthesis and structure-activity relationship (SAR) and QSAR studies. Bioorganic Chemistry. 2019;89:103015.10.1016/j.bioorg.2019.103015
- Savithri K, Kumar BCV, Vivek HK, Revanasiddappa HD. Synthesis and Characterization of Cobalt(III) and Copper(II) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol: DNA Binding and Nuclease Studies—SOD and Antimicrobial Activities. International Journal of Spectroscopy. 2018;2018:1-15.10.1155/2018/8759372
- Ravindar L, Bukhari SNA, Rakesh KP, et al. Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies. Bioorganic Chemistry. 2018;81:107-118.10.1016/j.bioorg.2018.08.001
- Rakesh KP, Vivek HK, Manukumar HM, et al. Promising bactericidal approach of dihydrazone analogues against bio-film forming Gram-negative bacteria and molecular mechanistic studies. RSC advances. 2018;8(10):5473-5483.10.1039/c7ra13661g
- Li C, Sridhara MB, Rakesh KP, et al. Multi-targeted dihydrazones as potent biotherapeutics. Bioorganic Chemistry. 2018;81:389-395.10.1016/j.bioorg.2018.08.024
- Lakshmi S, Shashidhara GM, Madhu GM, Muthappa R, Vivek HK, Nagendra Prasad MN. Characterization of peroxidase enzyme and detoxification of phenols using peroxidase enzyme obtained from Zea mays L waste. Applied Water Science. 2018;8(7).10.1007/s13201-018-0820-9
- Devegowda PS, Balaji KS, Prasanna DS, et al. Synthesis, Characterization of 4-Anilino-6,7-Dimethoxy Quinazoline Derivatives as Potential Anti-Angiogenic Agents. Anti-Cancer Agents in Medicinal Chemistry. 2018;17(14).10.2174/1871521409666170412120837
- Ashok NR, Vivek KH, Aparna HS. Antioxidative Role of Buffalo (Bubalus bubalis) Colostrum Whey Derived Peptides During Oxidative Damage. International Journal of Peptide Research and Therapeutics. 2018;25(4):1501-1508.10.1007/s10989-018-9795-5
- Zha G-F, Leng J, Darshini N, et al. Synthesis, SAR and molecular docking studies of benzo[d]thiazole-hydrazones as potential antibacterial and antifungal agents. Bioorganic & Medicinal Chemistry Letters. 2017;27(14):3148-3155.10.1016/j.bmcl.2017.05.032
- Wang S-M, Zha G-F, Rakesh KP, et al. Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H(+)/K(+) ATPase inhibitors and anti-inflammatory agents. Medchemcomm. 2017;8(6):1173-1189.10.1039/c7md00111h
- Uday P, Maheshwari M, Sharanappa P, et al. Exploring hemostatic and thrombolytic potential of heynein – A cysteine protease from Ervatamia heyneana latex. Journal of Ethnopharmacology. 2017;199:316-322.10.1016/j.jep.2016.12.047
- Renuka N, Vivek HK, Pavithra G, Ajay Kumar K. Synthesis of coumarin appended pyrazolyl-1,3,4-oxadiazoles and pyrazolyl-1,3,4-thiadiazoles: Evaluation of their in vitro antimicrobial and antioxidant activities and molecular docking studies. Russian Journal of Bioorganic Chemistry. 2017;43(2):197-210.10.1134/s106816201702011x
- Preethi Saligrama D, Vivek HK, Kyathegowdanadoddi Srinivasa B, et al. Synthesis, Characterization A Molecular Docking Studies of Anilinoquinazoline Derivatives. International Journal of Current Research. 2017;9(02):46509-46517.10.1107/s1600536810034677
- Lokeshwari DM, Rekha ND, Srinivasan B, Vivek HK, Kariyappa AK. Design, synthesis of novel furan appended benzothiazepine derivatives and in vitro biological evaluation as potent VRV-PL-8a and H+/K+ ATPase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2017;27(14):3048-3054.10.1016/j.bmcl.2017.05.059
- Kumar S, Basappa Chidananda VK, Hosakere Doddarevanna R, Hamse Kameshwar V, Kaur M, Jasinski JP. 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol; synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies. Journal of Molecular Structure. 2017;1142:293-303.10.1016/j.molstruc.2017.04.050
- Gurunanjappa P, Kameshwar VH, Kariyappa AK. Bioactive Formylpyrazole Analogues: Synthesis, Antimicrobial, Antioxidant and Molecular Docking Studies. Asian Journal of Chemistry. 2017;29(7):1549-1554.10.14233/ajchem.2017.20562
- Dileep Kumar A, Vivek HK, Mylarappa Bantaganahalli N, Ajay Kumar K. Synthesis and in vitro biological evaluation for antioxidant, anti-inflammatory activities and molecular docking studies of novel pyrazole derivatives. Biointerface Research in Applied Chemistry. 2017;7 (3):2040 – 2047
- Devirammanahalli ML, Vivek HK, Ajay Kumar K. Synthesis of furan tethered 2-pyrazolines via 1,3-dipolar cycloaddition reactions: In vitro evaluation for their antioxidant and antimicrobial activities, molecular docking and ADMET studies. Biointerface Research in Applied Chemistry. 2017;7(5):2158 – 2165
- Chen X, Leng J, Rakesh KP, et al. Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents. Medchemcomm. 2017;8(8):1706-1719.10.1039/c7md00209b
- Swamy SG, Kameshwar VH, Shubha PB, et al. Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma. Targeted Oncology. 2016;12(1):1-10.10.1007/s11523-016-0452-7
- Shivalingu BR, Vivek HK, Priya BS, Soujanya KN, Swamy SN. Purification and characterization of novel fibrin(ogen)olytic protease from Curcuma aromatica Salisb.: Role in hemostasis. Phytomedicine. 2016;23(13):1691-1698.10.1016/j.phymed.2016.09.007
- Raghavendra KR, Renuka N, Kameshwar VH, Srinivasan B, Ajay Kumar K, Shashikanth S. Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies. Bioorganic & Medicinal Chemistry Letters. 2016;26(15):3621-3625.10.1016/j.bmcl.2016.06.005
- Kameshwar VH, R KJ, Priya BS, Swamy SN. Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A2 from Vipera russelli. Molecular and Cellular Biochemistry. 2016;426(1-2):161-175.10.1007/s11010-016-2888-6
- Dileep Kumar A, Naveen S, Vivek HK, Prabhuswamy M, Lokanath NK, Ajay Kumar K. Synthesis, crystal and molecular structure of ethyl 2-(4-chlorobenzylidene)-3-oxobutanoate: Studies on antioxidant, antimicrobial activities and molecular docking. Chemical Data Collections. 2016;5-6:36-45.10.1016/j.cdc.2016.10.002
- Achar RR, Venkatesh BK, Vivek HK, Priya BS, Swamy SN. Caralluma umbellata Peroxidase: Biochemical Characterization and Its Detoxification Potentials in Comparison with Horseradish Peroxidase. Applied Biochemistry and Biotechnology. 2016;181(2):801-812.10.1007/s12010-016-2250-1
- Shivalingu BR, Vivek HK, Nafeesa Z, Priya BS, Swamy SN. Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species. Journal of Ethnopharmacology. 2015;172:261-264.10.1016/j.jep.2015.06.018
- Nafeesa Z, Shivalingu BR, Vivek HK, Priya BS, Swamy SN. Exploring a New Serine Protease from Cucumis sativus L. Applied Biochemistry and Biotechnology. 2015;175(6):2787-2794.10.1007/s12010-014-1462-5
- N NK, K VH, R KJ, Priya BS, Swamy SN. PURIFICATION AND BIOCHEMICAL CHARACTERIZATION OF L-AMINO ACID OXIDASE FROM WESTERN REGION INDIAN COBRA (NAJA NAJA) VENOM. International Journal of Pharmacy and Pharmaceutical Sciences. 2015;7(13):167-171
- Keerthy HK, Vivek HK, Bharathkumar H, et al. MOLPRINT 2D-based identification and synthesis of novel chromene based small molecules that target PLA2: validation through chemo- and bioinformatics approaches. RSC Advances. 2015;5(109):89797-89808.10.1039/c5ra13085a
- Vivek HK, Swamy SG, Priya BS, Sethi G, Rangappa KS, Nanjunda Swamy S. A facile assay to monitor secretory phospholipase A2 using 8-anilino-1-naphthalenesulfonic acid. Analytical Biochemistry. 2014;461:27-35.10.1016/j.ab.2014.05.024
- Divya K, Vivek HK, Nagendra Prasad MN, Priya BS, Nanjunda Swamy S. Management of Type 2 Diabetes Mellitus by DPP-IV Inhibition – A Review. International Journal of Pharmaceutical and Phytopharmacological Research. 2014;4(2):2
- Mohamed R, Tarannum S, Yariswamy M, et al. Ascorbic acid 6-palmitate: a potent inhibitor of human and soybean lipoxygenase-dependent lipid peroxidation. Journal of Pharmacy and Pharmacology. 2013;66(6):769-778.10.1111/jphp.12200
- Nagendra PMN, Vivek HK, Ashwini P, et al. Antifungal activities of novel synthetic compounds against Phomopsis azadirachtae- the causative agent of die-back disease of neem Journal of Chemical and Pharmaceutical Research. 2010;2(3):567-574
- Mahendra M, Vivek HK, Gaonkar SL, Priya BS, Nanjunda Swamy S. 1-(3-Bromo-2-thien-yl)ethanone. Acta crystallographica. Section E, Structure reports online. 2010;66(Pt 10):o2540.10.1107/s1600536810034677
Awards
| Title | Governing body | Year |
Spot award |
Syngene International limited |
2017 |
Ph. D Assistantship |
Technical Education Quality Improvement Programme (TEQIP) (Govt of India) |
2014 |
Senior Research Fellow |
Council for Scientific and Industrial Research (Govt of India) |
2012 |
