M.Sc.: Molecular Biology,
University of Mysore, Mysuru, Karnataka, India.

Ph.D: Cell Biology,
Department of BioMaterials, Chosun University, South Korea (With Prof. Ho Jin You)

• Currently working on elucidation of molecular mechanism involved in induction of apoptosis in cancer cells by various natural derived small molecules. He is also involved in screening of natural derived small molecules to identify potent natural entity to target aberrantly overexpressed Protein pathway (PI3K/mTOR pathway and AMPK/STAT3) and DNA repair pathway enzymes to mitigate childhood carcinoma (Rhabdomayosarcoma).
• Working in unraveling the molecular connection with microRNA regulating expression of oncogenic and tumor suppressor genes in modulating the cancer cells.
• In collaboration with AH&RC, he is involved in establishment of tumour sample database by cumulative collection of excised tumour sample to analyze variations in gene expression pattern and functions of aberrantly over expressed genes and to study mutational status in patient tumour samples.

1. 1. Saad KR, Kumar G, Puthusseri B, Srinivasa SM, Giridhar P, Shetty NP. Genome-wide identification of MATE, functional analysis and molecular dynamics of DcMATE21 involved in anthocyanin accumulation in Daucus carota. Phytochemistry. 2023 Apr 12:113676. doi: 10.1016/j.phytochem.2023.113676.  Impact factor: 4.004 (Scimago Q1)
   2. Yarabahally R Girish, Kothanahally S Sharathkumar, Kalappa Prashantha, Shobith Rangappa, Muddenahalli S Sudhanva. Significance of antioxidants and methods to evaluate their potency. Materials Chemistry Horizons. 2023 Mar.doi: 10.22128/MCH.2023.647.1037
   3. Jagadeesha G.S1❖ , Sudhanva M.S2,3❖, Akshay Uttarkar4, Anil Kumar B.M2, Shwetha B5, Sridhar B.T6, Vidya Niranjan4, Manjula R.V2, Shobith R2,3, Thimmegowda N.R1, Rangappa K.S, Novel 1,2,5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells. ACS Omega. 2022 Dec 6;7(50):46955–71. https://doi.org/10.1021/acsomega.2c06057                    Impact factor: 4.132 (Scimago Q1)
   4. Pradeep S, Prabhuswaminath SC, Reddy P, Srinivasa SM, Shati AA, Alfaifi MY, Eldin I Elbehairi S, Achar RR, Silina E, Stupin V, Manturova N, Glossman-Mitnik D, Shivamallu C, Kollur SP. Anticholinesterase activity of Areca Catechu: In Vitro and in silico green synthesis approach in search for therapeutic agents against Alzheimer’s disease. Front Pharmacol. 2022 Nov 4;13:1044248. https://doi.org/10.3389/fphar.2022.1044248    Impact factor: 5.988 (Scimago Q1)
   5. Vasappanavara Sreenatha, PhD; Sudhanva M Srinivasa, PhD, Rajendra prasad, Design, Synthesis, Bioevaluation, DFT, Docking and Molecular Dynamic Simulation for Selected Novel 1,3,4-Oxadiazole – Indole Derivatives Hybrid against Estrogen Receptor alpha, Journal of Molecular Structure, 1269 (2022), 133789. https://doi.org/10.1016/j.molstruc.2022.133789       Impact factor: 3.841 (Scimago Q2)
   6. Yarabahally R. Girish1#*, BM Anil Kumar2#, Kothanahally S. Sharath Kumar4, Vivek K Hamse1, Milad Ashrafizadeh4,5, Ali Zarrabi6, Prashantha K4, MS Sudhanva2,3*, Shobith R2*, Identification of novel benzimidazoles based small molecule targeting dual targets Tankyrase and Bcl2 to induce apoptosis in Colon cancer cells, Journal of Molecular Structure, 1269, (2022), 133813. https://doi.org/10.1016/j.molstruc.2022.133813    Impact factor: 3.841 (Scimago Q2)
   7. Sudhanva, M.S.; Hariharasudhan, G.; Jun, S.; Seo, G.; Kamalakannan, R.; Kim, H.H.; Lee, J.-H. MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs. Cells 2022, 11, (9) 1509. https://doi.org/10.3390/cells11091509  Impact factor: 7.666 (Scimago Q1)
   8. B. Shwetha1, M.S. Sudhanva2, N.R. Thimmegowda3, B.M. Anil Kumar2, G.S. Jagadeesha3, H. Guddappa1, D.S. Prasanna1, R. Dinesh1, R. Shobith2*, and C.S. Anandakumar1*, Synthesis of Caffeic Acid Derivatives: Identification of (E)-N-(4-Cyanobenzyl)-3-(3,4-dihydroxyphenyl)acrylamide as an Anticancer Agent against Human Cervical Cancer Cells Asian J. Chem. / 2022 / 34(8) / pp 2183-2190. https://doi.org/10.1016/j.bioorg.2020.104586
   9. Maliyappa, M.R., Keshavayya, J., Nazrulla, M.A., Sudhanva M.S., & Shobith Rangappa, Six-substituted benzothiazole based dispersed azo dyes having antipyrine moiety: synthesis, characterization, DFT, antimicrobial, anticancer and molecular docking studies. J IRAN CHEM SOC (2022), 19, 3815-3835.   Impact factor: 2.271 (Scimago Q3)
   10. Akshay Uttarkar; Alice Preethi K; Sudhanva M Srinivas; Shobith Rangappa; Raviraj Kusanur, Vidya Niranjan. Coumarin derivative as a potent drug candidate against Triple Negative Breast Cancer targeting the Frizzled receptor of Wingless-related integration site signaling pathway, Journal of Biomolecular Structure and Dynamics. 2021, 1-13. https://doi.org/10.1080/07391102.2021.2022536 Impact factor: 5.235 (Scimago Q1)
   11. Maliyappa M.R, Ph.D; Sudhanva M.S, Ph.D; Pushpavathi I, Ph.D; Vinod kumar, Ph.D. Dr. Keshavayya Jathi. Maliyappa M.R, Ph.D; Sudhanva M.S, Ph.D; Pushpavathi I, Ph.D; Vinod kumar, Ph.D. Dr. Keshavayya Jathi. Heterocyclic azo dyes derived from 2-(6-chloro-1,3-benzothiazol-2-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one having benzothiazole skeleton: Synthesis, structural, computational and biological studies, Journal of molecular Structures, 2021, 1247, 131321.  https://doi.org/10.1016/j.molstruc.2021.131321       Impact factor: 3.841 (Scimago Q2)
   12. Reshma Sathyanarayana, Boja Poojary, Sudhanva M Srinivasa, Vijay K Merugumolu, Revanasiddappa B Chandrashekarappa, Shobith Rangappa “In vitro, in vivo and in silico driven identification of novel benzimidazole derivatives as anticancer and anti-inflammatory agents”, Journal of the Iranian Chemical Society 2021, 1-17. https://doi.org/10.1007/s13738-021-02381-y       Impact factor: 2.271 (Scimago Q3)
   13. Shivaraja Govindaiah, M.Sc.; Sanay Naha, Ph.D.; Tadimety Madhuchakrapani Rao; B.C. Revanasiddappa, Ph.D.; Sudhanva M. Srinivasa, Ph.D.; L. Parashuram, Ph.D.; Sivan Velmathi, Ph.D. Swamy Sreenivasa. Sulfated Magnesium Zirconate catalyzed Synthesis, Antimicrobial, Antioxidant, Anti-inflammatory, and Anticancer Activity of Benzo[d]thiazole-Hydrazone Analogues and its Molecular Docking, Results in chemistry, 2021. https://doi.org/10.1016/j.rechem.2021.100197 Impact factor: yet to be announced (Scimago Q3)
   14. Shwetha B❖, Muddenahalli S Sudhanva❖, Jagadeesha G.S, Thimmegowda N.R, Vivek K Hamse, Sridhar B.T, Ananda Kumar C.S#, Shobith R#, Rangappa K.S: Furan-2-Carboxamide derivative, A Novel Microtubule Stabilizing Agent Induces Mitotic Arrest and Potentiates Apoptosis in Cancer Cells. Bioorganic Chemistry, 2021, 108, 104586.  https://doi.org/10.1016/j.bioorg.2020.104586   Impact factor: 5.307 (Scimago Q1)
   15. Seegehalli M Anil❖, Muddenahalli S Sudhanva❖, Toreshettahally R Swaroop, Ajjampura C Vinayaka, Narasimhamurthy Rajeev, Kuppalli R Kiran, Rangappa Shobith, M P Sadashiva Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi‐Substituted Δ2‐Pyrrolines and Their Cytotoxicity, Chemistry & Biodiversity, 2020, 17, 5, e2000014. DOI: 10.1002/cbdv.202000014                 Impact factor: 2.745 (Scimago Q2)
   16. Vinod Kumar, J Keshavayya, Mallikarjuna N Matada, Sudhanva M Srinivasa, S Rangappa, Synthesis, Characterization and Biological Potency of Butyl‐Pyridone Based Azo Dyes: Chemistry Select, 2020, 5, 18, 5460-5464 DOI: 10.1002/slct.201904954     Impact factor: 2.307 (Scimago Q2)
   17. Ananda H, Sharath Kumar KS, Sudhanva MS, Shobith R,* Rangappa KS*; A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression; Molecular and Cellular Biochemistry, 2018, 449, 137–144. DOI: 0.1007/s11010-018-3350-8 Impact factor: 3.842 (Scimago Q1)
   18. Jin Myung Choia, Yun Hui Choic, Muddenahalli Srinivasa Sudhanva, Sundaravinayagam Devakumar, Kun Ho Lee, Jeong-Heon Cha, and Sung Haeng Lee. Crystal structure of CagL from Helicobacter pylori K74 strain; Biochemical and Biophysical Research Communications, 2014, 460, 4, 964-970. DOI : 10.1016/j.bbrc.2015.03.135            Impact factor: 3.322 (Scimago Q2)
   19. Nanishankar V.Harohally, Sudhanva M. Srinivasa, Sushma Umesh. ZnCl2-mediated practical protocol for the synthesis of Amadori ketoses; Food Chemistry, 2014, 158, 340-344. DOI: 10.1016/j.foodchem.2014.02.094  Impact factor: 9.231 (Scimago Q1)
   20. Eun Jeong Kim,† Jeeho Kim,† Min Young Lee, Muddenahalli Srinivasa Sudhanva, Sundaravinayagam Devakumar, and Young Jin Jeon*. Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway: Biomol Ther (Seoul), 2014 Jul; 22(4): 282–287. DOI     : 10.4062/biomolther.2014.072     

Impact factor: 4.231 (Scimago Q1)

1. Sudhanva M. Srinivasa, Nanishankar V. Harohally* Improved Synthesis of Lysine- and Arginine-Derived Amadori and Heyns Products and in Vitro Measurement of their Angiotensin I-Converting Enzyme Inhibitory Activity, J. Agric. Food Chem. 2012, 60, 6, 1522-1527. DOI: 10.1021/jf204185y        Impact factor: 5.895 (Scimago Q1)

1. Devearaj Reddy, Prathvi Shetty, Srilakshmi Alluri, Shobith Rangappa, Sudhanva M S, Shreya K “A composition of neem leaf water-soluble bitters and a process of preparation thereof”
   Patent filed on December 21, 2022.
   Application Number: 202241074158
2. Devearaj Reddy, Prathvi Shetty, Srilakshmi Alluri, Shobith Rangappa, Sudhanva M S, Shreya K “A bioactive bacopa extract and bitterless Ebelin lactone composition and a process of preparation thereof”
   Patent filed on January 12, 2023.
   Application Number: 202341002516

    

3. Devearaj Reddy, Prathvi Shetty, Srilakshmi Alluri, Shobith Rangappa, Sudhanva M S, Shreya K “A composition of highly bioabsorbable ashwagandha root extract and a process of preparation thereof”
   Patent filed on January 12, 2023.
   Application Number: 202341002519

• Availed South Korean Government scholarship for pursuing Doctor of Science (Chosun University, South Korea)
• Best oral presentation in Second International on Advanced Materials for Health, Energy and Environment (AMHEE-2023) at JSSTU, Mysore.