M.Sc: Molecular Biology,
University of Mysore,
Mysuru.

Ph.D: Life Science,
Faculty of Advanced Life science,
Hokkaido University, Japan.

1. Dr. Devaraj reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M S Sudhnava and Shreya Uday. A composition of neem leaf water-soluble bitters and a process of preparation thereof.
   Patent filed on December 21, 2022.
   Application Number: 202241074158
2. Dr. Devaraj reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M S Sudhnava and Shreya Uday. A bioactive bacopa extract and bitterless Ebelin lactone composition and a process of preparation thereof.
   Patent filed on January 12, 2023.
   Application Number: 202341002516
3. Dr. Devaraj reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M S Sudhnava and Shreya Uday. A composition of highly bioabsorbable ashwagandha root extract and a process of preparation thereof.
   Patent filed on January 12, 2023.
   Application Number: 202341002519
4. Rangappa KS, Basappa, Mohan CD, Shobith R, Bharathkumar H, Sethi G, Bender A, Lobie PE, Hui KM, Kumar AP, Pandey VK, Fuchs J, Shanmugam MK, Bulusu K, Dai X, Li F, Deivasigamani A; “Compounds as modulator of JAK-STAT pathway, methods and applications thereof” (Granted).US Patent, 15/004114 dated 22-01-2016; Pub. No. US 2016/0214968 A1 dated 28-07- 2016
5. Rangappa KS, Basappa, Mohan CD, Shobith R, Keerthy HK, Sethi G, Bender A, Girish KS, Fuchs J, Sundaram MS, Li F, Siveen KS; “Compounds as modulators of tumor necrosis factor, methods and applications thereof”, Indian Patent, 4345/CHE/2015 A Publication dated24- 02-2017.
6. Peter Edward Lobie, Vijay Kumar Pandey, Ranpappa Kanchugarakoppal Subbegowda, Bassappa Salundi, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa, Srinivasa Venkatachalaiah; “Small molecule inhibitors of bcl-2-associated death promoter (bad) phosphorylation” US patent- 16605630 dated 2020/4/30
7. Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppalsubbegowda, Basappa Basappa, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa; “Compounds useful in inhibiting human trefoil factor 3” US patent – 16619218 dated 2020/5/14

8. Rangappa S, Swathantraiah JG, Srinivas SM, Belagal Motatis AK, Bettaswamygowda S, Subbegowda RK, Ramegowda TN.
   Substituted Benzimidazole compounds as potent inhibitors of AKT phosphorylation.
   Patent Filed: September 2024
   Application Number: 202441075008

9. Dr. Devaraj Reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M. S. Sudhnava, Shreya Uday.
   A composition of neem leaf water-soluble bitters and a process of preparation thereof.
   Patent Filed: December 21, 2022
   Application Number: 202241074158

10. Dr. Devaraj Reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M. S. Sudhnava, Shreya Uday.
    A bioactive bacopa extract and bitterless Ebelin lactone composition and a process of preparation thereof.
    Patent Filed: January 12, 2023
    Application Number: 202341002516

11. Dr. Devaraj Reddy, Dr. Prathvi Shetty, Dr. Srilakshmi Aluri, Dr. Shobith Rangappa, Dr. M. S. Sudhnava, Shreya Uday.
    A composition of highly bioabsorbable ashwagandha root extract and a process of preparation thereof.
    Patent Filed: January 12, 2023
    Application Number: 202341002519

12. Rangappa KS, Basappa, Mohan CD, Shobith R, Bharathkumar H, Sethi G, Bender A, Lobie PE, Hui KM, Kumar AP, Pandey VK, Fuchs J, Shanmugam MK, Bulusu K, Dai X, Li F, Deivasigamani A.
    Compounds as modulators of JAK-STAT pathway, methods and applications thereof. (Granted)
    US Patent: 15/004114 (22-01-2016)
    Publication No.: US 2016/0214968 A1 (28-07-2016)

13. Rangappa KS, Basappa, Mohan CD, Shobith R, Keerthy HK, Sethi G, Bender A, Girish KS, Fuchs J, Sundaram MS, Li F, Siveen KS.
    Compounds as modulators of tumor necrosis factor, methods and applications thereof.
    Indian Patent: 4345/CHE/2015 A
    Publication Date: 24-02-2017

14. Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppal Subbegowda, Basappa Salundi, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa, Srinivasa Venkatachalaiah.
    Small molecule inhibitors of bcl-2-associated death promoter (BAD) phosphorylation.
    US Patent: 16605630
    Date: 2020/4/30

15. Peter Edward Lobie, Vijay Kumar Pandey, Rangappa Kanchugarakoppalsubbegowda, Basappa Basappa, Mohan Chakrabhavi Dhananjaya, Shobith Rangappa.
    Compounds useful in inhibiting human trefoil factor 3.
    US Patent: 16619218
    Date: 2020/5/14

Cancer Biology, Chemical Biology and Glycobiology

• Elected as Executive Committee Member for Indian Science Congress 2023-2024
• Awarded with prestigious JASSO fellowship award (2022) from Japan for continuing the research collaboration with Hokkaido University.
• Awarded VGST KFIST-L1 (15 Lakhs) project from Government of Karnataka for research project “Sensitization of Triple Negative Breast cancer cells to DOXO by garcinol and pathway elucidation studies in nude mice tumor model”(2022)
• National Award: Prof. R C Shah Memorial Lecture Award of 2018-19 (ISCA) recognition.
• Elected as member of the sectional committee of the section of chemical sciences for 2019- 2020 (ISCA)
• Best Poster award received from Vision Group on Science and Technology (VGST) Government of Karnataka (2018)
• Excellent Presentation award for poster session at 3rd International life Science Symposium held at Hokkaido University Japan (2015).
• National Award: Biotech Research Society of India awarded him with MKU-SBS Genomics Award 2024
• Elected as Executive Committee Member for Indian Science Congress 2023-2024
• Awarded with prestigious JASSO fellowship award (2022) from Japan for continuing the research collaboration with Hokkaido University.
• National Award: R C Shah Memorial Lecture Award of 2018-19 (ISCA) recognition.
• Elected as member of the sectional committee of the section of chemical sciences for 2019-2020 (ISCA)
• Best Poster award for research publication received from Vision Group on Science and Technology (VGST) Government of Karnataka (2018)
• Excellent Presentation award for poster session at 3rd International life Science Symposium held at Hokkaido University Japan (2015).
• Chaired and co-chaired several plenary sessions of ISCA and its local chapters, other national and international conference.
• BOS Member of various PG programs of University of Mysore and Adichunchanagiri university
• Examination superintendent of Adichunchanagiri School of Natural Sciences.
• 1. Hanumesh P, Mundugaru R, Amita K, Prashantha K, Rangappa S. Biological assessment of 3-phenylpropyl acetate as a wound healing agent. Journal of Biologically Active Products from Nature. 2025 Oct 9:1-9.
  2. Thammanna Gowda SS, Shobith Rangappa, and Parimala Hanumesh. The Impact of Epigenetic Factors in Type 2 Diabetes: Insights into Development and Pathogenesis. Obesity Medicine. 2025 Jul 11:100635.
  3. Ramakrishnegowda DH, Ramesh SB, Chandrakantha KS, Rangappa S, Rangappa KS, Sadashiva MP. Multi-functional Ag2O-NiO composite bio-catalyst: Efficacy in breast cancer and anti-microbial properties. Next Materials. 2025 Jul 1;8:100625.
  4. Prashanth DP, Ningaraju GN, Rangappa S, Rangappa KS, Karthik CS. Exploring the potential of thiazole derivatives in modulating the Wnt/β-catenin pathway for colon cancer therapy. Discover Molecules. 2025 Jun 16;2(1):16.
  5. Rajesh SM, Gowda B, Srinivasa SM, Swaroop TR, Suresh RN, Shalini VG, Preetham HD, Shobith R, Rangappa KS. Synthesis of spiro [cyclopropane-isatin] derivatives and their therapeutic potential as anticancer agents against colorectal carcinoma. Results in Chemistry. 2025 May 21:102368.
  6. Rajesh SM, Doddakunche Shivaramu P, Bhol CS, Swaroop TR, Preetham HD, Suresh RN, Chinnathambi A, Govindasamy C, Alharbi SA, Shalini VG, …. Shobith Rangappa*, Kanchugarakoppal S Rangappa*. 1, 2, 3‐Triazole Tethered Spiro [Indoline‐Oxirane] Derivatives Induce Anticancer Effects in Human Hepatoma Cells. Chemical Biology & Drug Design. 2025 Apr;105(4):e70091.
  7. Poojashree YK, Anilkumar BM, Karuppannan S, Priyadarshini AN, Prashantha K, Nagarajaiah H, Sudhanva MS, Shobith R*, Girish YR*. Synergic antibacterial activity of Guar gum functionalized 2D-MoS2-Gelatin-Ag nanocomposites. Inorganic Chemistry Communications. 2025 Mar 8:114296.
  8. Gowda D, Kumar DV, Gowda B, Chethan BS, Harsha KB, Shalini V, Sudhanva MS, Shobith R*, Rangappa KS*. A Comprehensive Investigation of 4-(4-chlorophenyl)-3-methyl-6, 7, 8, 9-tetrahydroisoxazolo [5, 4-b] quinolin-5 (4H)-one as Potential Anticancer Agent: Insights from Computational and Experimental Results Through Crystal Structure Analysis. Journal of Molecular Structure. 2025 Jan 19:141489.
  9. Sudhanva MS, Anush SM, Sharathkumar KS, Rangappa S*, Girish YR. Antioxidant Activity of Green Biomaterials. InGreen Biomaterials in Tissue Engineering 2025 (pp. 207-228). American Chemical Society.
  10. Dhanalakshmi B, Anil Kumar BM, Muddenahalli Srinivasa S, Vivek HK, Sennappan M, Rangappa S*, Srinivasa Murthy V. Design and synthesis of 4-aminophenol-1, 3, 4-oxadiazole derivative potentiates apoptosis by targeting MAP kinase in triple negative breast cancer cells. Journal of Biomolecular Structure and Dynamics. 2024 Dec 16;42(23):13114-29.
  11. Hanumesh P, Rangappa S*. An Overview of 3‐Phenylpropyl Acetate: A Multifaceted Fragrance and Flavouring Compound. Flavour and Fragrance Journal. 2024 Dec 13:40(2):183-189.
  12. Rangappa S*. Garcinol, a natural benzophenone overcomes radio and chemoresistance by targeting PI3K-PKB/AKT pathway in rhabdomyosarcoma cells. Journal of Biomolecular Structure and Dynamics. 2024 Dec 7:1-6. (Single Author Paper)
  13. Shalini V, Priyadarshini AN, DC VK, Gowda D, Chethan BS, Srinivasa SM, Rangappa S*, Rangappa KS*. Novel quinoline-4-carboxamide derivatives potentiates apoptosis by targeting PDK1 to overcome chemo-resistance in colorectal cancer: Theoretical and experimental results. Heliyon. 2024 Oct 15;10(19).
  14. Suresh NC, Kumar BA, Preetham HD, Srinivasa SM, Ali MS, Al-Lohedan HA, Kumar KS, Shivamallu C, Jain A, Rangappa S*, Umashankara M. Synthesis, molecular docking and pharmacological studies of novel quinoline derivative as anticancer agent that targets topoisomerase IIB. Journal of Molecular Structure. 2024 Sep 15;1312:138519.
  15. KN DR, Aluri S, Shetty P, Udaya S, Prasad S, Sudhanva MS, Rangappa S*. Assessing the Efficacy and Biological Benefits of Withanolide-rich Withania somnifera Root Extract. Annual Research & Review in Biology. 2024 May 8;39(5):54-64.
  16. Verma SK, Rangappa S, Verma R, Xue F, Verma S, Kumar KS, Rangappa KS. Sulfur (SⅥ)-containing heterocyclic hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and its SAR. Bioorganic Chemistry. 2024 Feb 25:107241.
  17. Preetham HD, Sharath Kumar KS, Kandaswamy A, Rangappa S, Gatasheh MK, Muddegowda U, Rangappa KS. Alternative Approach to Access 5-Hydroxy-1H-pyrrol-2-(5H)-ones from Base-Induced Tandem Intramolecular Cyclization of Sulfur Ylide with Ketones and 1, 3-Hydroxy Rearrangement. ACS omega. 2023 Dec 4;8(50), 48251–4825.
  18. Ramakrishnegowda DH, Chandrakantha KS, Urs D, Elfeky M, Krishnegowda J, Rangappa S, Rangappa KS, Shivanna S. Synthesis of p-CuO/n-ZnO heterostructure by microwave hydrothermal method and evaluation of its photo and bio-catalytic performance. 2023 Dec 1;9(12).
  19. Dhanalakshmi B, Anil Kumar BM, Muddenahalli Srinivasa S, Vivek HK, Sennappan M, Rangappa S*, Srinivasa Murthy V. Design and synthesis of 4-aminophenol-1, 3, 4-oxadiazole derivative potentiates apoptosis by targeting MAP kinase in triple negative breast cancer cells. Journal of Biomolecular Structure and Dynamics. 2023 Oct 23:1-6. Impact Factor: 5.235
  20. Dhanalakshmi B, Anil Kumar BM, Srinivasa Murthy V, Srinivasa SM, Vivek HK, Sennappan M, Rangappa S* Design, synthesis and docking studies of novel 4-aminophenol-1, 2, 4-oxadiazole hybrids as apoptosis inducers against triple negative breast cancer cells targeting MAP kinase. Journal of Biomolecular Structure and Dynamics. 2023 Jul 24:1-7. Impact Factor: 5.235
  21. Deveshegowda SN, Yang JR, Xi Z, Nagaraja O, Fazl-Ur-Rahman K, Narasimhachar BC, Sethi G, Periyasamy G, Madegowda M, Rangappa S, Pandey V. Nano-ZrO2-Catalyzed Biginelli Reaction and the Synthesis of bioactive Dihydropyrimidinones That Targets PPAR-γ in Human Breast Cancer Cells Catalysts. 2023 Feb;13(2):228. Citation:1
  22. Ashrafizadeh, Milad, Chakrabhavi D. Mohan, Shobith Rangappa, Ali Zarrabi, Kiavash Hushmandi, Alan Prem Kumar, Gautam Sethi, and Kanchugarakoppal S. Rangappa. Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: roles in cancer progression and therapeutic response. Medicinal Research Reviews. 2023 Mar; 1- 59. Citation: 10
  23. Ramakrishnegowda DH, Swamy CK, Kumar BA, Rangappa S, Rangappa KS, Shivanna S. Ag mediated plasmonic AgO/ZnO composite and its pharmaceutical relevance. Materials Science and Engineering: B. 2023 Jun 1;292:116437. Citation:0
  24. Girish YR, Sharathkumar KS, Prashantha K, Rangappa S*, Sudhanva MS. Significance of antioxidants and methods to evaluate their potency. Materials Chemistry Horizons. 2023 Mar 2(2), 93-112. Citation: 03
  25. Swathantraiah JG, Srinivasa SM, Belagal Motatis AK, Uttarkar A, Bettaswamygowda S, Thimmaiah SB, Niranjan V, Rangappa S*, Subbegowda RK, Ramegowda TN. Novel 1, 2, 5-Trisubstituted Benzimidazoles Potentiate Apoptosis by Mitochondrial Dysfunction in Panel of Cancer Cells. ACS omega. 2022 Dec 6;7(50):46955-71. Citation:1
  26. Girish YR, Kumar BA, Kumar KS, Hamse VK, Prashantha K, Sudhanva MS, Shobith R*. Identification of novel benzimidazole-based small molecule targeting dual targets Tankyrase and Bcl2 to induce apoptosis in Colon cancer. Journal of Molecular Structure. 2022 Dec 5;1269:133813. Citation:2
  27. Jung YY, Mohan CD, Rangappa S, Um JY, Chinnathambi A, Alharbi SA, Rangappa KS, Ahn KS. Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway.. IUBMB life. 2023 Feb;75(2):149-60. Citation:1
  28. Preetham HD, Muddegowda U, Sharath Kumar KS, Rangappa S, Rangappa KS. Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer’s disease. Journal of Peptide Science. 2022 Jun;28(6):e3386. Citation:4
  29. Maliyappa MR, Keshavayya J, Nazrulla MA, Sudhanva MS, Rangappa S. Six-substituted benzothiazole based dispersed azo dyes having antipyrine moiety: synthesis, characterization, DFT, antimicrobial, anticancer and molecular docking studies. Journal of the Iranian Chemical Society. 2022 Sep;19(9):3815-35. Citation:4
  30. Deveshegowda SN, Metri PK, Shivakumar R, Yang JR, Rangappa S, Swamynayaka A, Shanmugam MK, Nagaraja O, Madegowda M, Babu Shubha P, Chinnathambi A. Development of 1-(4-(Substituted) piperazin-1-yl)-2-((2-((4-methoxybenzyl) thio) pyrimidin-4-yl) oxy) ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells. Molecules. 2022 Apr 29;27(9):2848. Citation:2
  31. Sathyanarayana R, Poojary B, Srinivasa SM, Merugumolu VK, Chandrashekarappa RB, Rangappa S*. In vitro, in vivo and in silico-driven identification of novel benzimidazole derivatives as anticancer and anti-inflammatory agents. Journal of the Iranian Chemical Society. 2022 Apr;19(4):1301-17. Citation:2
  32. Sin ZW, Mohan CD, Chinnathambi A, Govindasamy C, Rangappa S, Rangappa KS, Jung YY, Ahn KS. Leelamine Exerts Antineoplastic Effects in Association with Modulating Mitogen‑Activated Protein Kinase Signaling Cascade. Nutrition and Cancer. 2022 Aug 13;74(9):3375-87. 2022 Aug 13;74(9):3375-87. Citation:2
  33. Preetham HD, Umashankara M, Kumar KS, Rangappa S, Rangappa KS. Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent. Medicinal Chemistry Research. 2022 Mar;31(3):507-16. Citation:2
  34. Vishwanath D, Girimanchanaika SS, Dukanya D, Rangappa S, Yang JR, Pandey V, Lobie PE, Basappa B. Design and activity of novel oxadiazole based compounds that target Poly (ADP-ribose) polymerase. Molecules. 2022 Jan 21;27(3):703. Citation:4
  35. Mohan CD, Yang MH, Rangappa S, Chinnathambi A, Alharbi SA, Alahmadi TA, Deivasigamani A, Hui KM, Sethi G, Rangappa KS, Ahn KS. 3-formylchromone counteracts STAT3 signaling pathway by elevating SHP-2 expression in hepatocellular carcinoma. Biology. 2021 Dec 26;11(1):29. Citation:13
  36. Uttarkar A, Kishore AP, Srinivas SM, Rangappa S*, Kusanur R, Niranjan V. Coumarin derivative as a potent drug candidate against triple negative breast cancer targeting the frizzled receptor of wingless-related integration site signaling pathway. Journal of Biomolecular Structure and Dynamics. 2021 Dec 24:1-3. Citation:9
  37. Mohan CD, Kim C, Siveen KS, Manu KA, Rangappa S, Chinnathambi A, Alharbi SA, Rangappa KS, Kumar AP, Ahn KS. Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma. IUBMB life. 2021 Nov;73(11):1348-62. Citation:19
  38. Arora L, Mohan CD, Yang MH, Rangappa S, Deivasigamani A, Kumar AP, Kunnumakkara AB, Garg M, Chinnathambi A, Alharbi SA, Alahmadi TA. Tris (dibenzylideneacetone) dipalladium (0)(Tris DBA) abrogates tumor progression in hepatocellular carcinoma and multiple myeloma preclinical models by regulating the STAT3 signaling pathway. 2021 Oct 31;13(21):5479. Citation:18
  39. Sajith AM, Narasimhamurthy KH, Shanmugam MK, Rangappa S, Nayak SC, Chinnathambi A, Alahmadi TA, Alharbi SA, Haridas KR, Reddy EK, Savitha B. Pyrimidine-2, 4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorganic & Medicinal Chemistry Letters. 2021 Oct 15;50:128332. Citation:5
  40. Kumar KS, Ananda H, Rangappa S, Raghavan SC, Rangappa KS. Regioselective competitive synthesis of 3, 5-bis (het) aryl pyrrole-2-carboxylates/carbonitriles vs. β-enaminones from β-thioxoketones. Tetrahedron Letters. 2021 Oct 12;82:153373. Citation:5
  41. Zha GF, Preetham HD, Rangappa S, Kumar KS, Girish YR, Rakesh KP, Ashrafizadeh M, Zarrabi A, Rangappa KS. Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies. Bioorganic Chemistry. 2021 Oct 1;115:105175. Citation:37
  42. Mohan CD, Rangappa S, Nayak SC, Sethi G, Rangappa KS. Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2021 Aug 1;1876(1):188574. Citation:37
  43. Barash U, Rangappa S, Mohan CD, Vishwanath D, Boyango I, Basappa B, Vlodavsky I, Rangappa KS. New heparanase-inhibiting triazolo-thiadiazoles attenuate primary tumor growth and metastasis. Cancers. 2021 Jun 13;13(12):2959. Citation:6
  44. Mohan CD, Rangappa S, Nayak SC, Jadimurthy R, Wang L, Sethi G, Garg M, Rangappa KS Bacteria as a treasure house of secondary metabolites with anticancer potential.. In Seminars in cancer biology. 2022 Nov 1 (86) 998-1013. Citation:31
  45. Mohan CD, Liew YY, Jung YY, Rangappa S, Preetham HD, Chinnathambi A, Alahmadi TA, Alharbi SA, Lin ZX, Rangappa KS, Ahn KS. Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells. 2021 Mar 1;182:140-51. Citation:19
  46. Shwetha B, Sudhanva MS, Jagadeesha GS, Thimmegowda NR, Hamse VK, Sridhar BT, Thimmaiah KN, Kumar CA, Shobith R*, Rangappa KS.Furan-2-carboxamide derivative, a novel microtubule stabilizing agent induces mitotic arrest and potentiates apoptosis in cancer cells. Bioorganic Chemistry. 2021 Mar 1;108:104586. Citation:10
  47. Siddaiah C, Kumar BM A, Deepak SA, Lateef SS, Nagpal S, Rangappa KS, Mohan CD, Rangappa S, Kumar S M, Sharma M, Gupta VK. Metabolite Profiling of Alangium salviifolium Bark Using Advanced LC/MS and GC/Q-TOF Technology. 2020 Dec 22;10(1):1. Citation:5
  48. Lee JH, Mohan CD, Deivasigamani A, Jung YY, Rangappa S, Basappa S, Chinnathambi A, Alahmadi TA, Alharbi SA, Garg M, Lin ZX. Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Advanced Research. Citation:93
  49. Malojirao VH, Girimanchanaika SS, Shanmugam MK, Sherapura A, Metri PK, Vigneshwaran V, Chinnathambi A, Alharbi SA, Rangappa S, Mohan CD, Prabhakar BT. Novel 1, 3, 4-oxadiazole targets STAT3 signaling to induce antitumor effect in lung cancer. 2020 Sep 21;8(9):368. Citation:14
  50. Kalagatur NK, Gurunathan S, Kamasani JR, Gunti L, Kadirvelu K, Mohan CD, Rangappa S, Prasad R, Almeida F, Mudili V, Siddaiah C. Inhibitory effect of C. zeylanicum, C. longa, O. basilicum, Z. officinale, and C. martini essential oils on growth and ochratoxin A content of A. ochraceous and P. verrucosum in maize grains. Biotechnology Reports. 2020 Sep 1;27:e00490. Citation:17
  51. Shanmugam MK, Rangappa S, Metri PK, Mohan S, Rangappa KS. Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells. Bioorganic & Medicinal Chemistry Letters. 2020 Aug 15;30(16):127330. Citation:9
  52. Shanmugam MK, Rangappa S, Metri PK, Mohan S, Rangappa KS. Anti-proliferative activity and characterization data on oxadiazole derivatives. Data in Brief. 2020 Aug 1;31:105979. Citation:0
  53. Lee JH, Mohan CD, Shanmugam MK, Rangappa S, Sethi G, Siveen KS, Chinnathambi A, Alahmadi TA, Alharbi SA, Basappa S, Rangappa KS. Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway. 2020 Aug 1;175:58-68. Citation:45
  54. Aiyaz M, Divakara ST, Konappa NM, Kalagattur NK, Satyanarayana NR, Mohan CD, Rangappa S, Chandranayaka S, Niranjana SR. Genetic and chemotypic diversity of two lineages of Aspergillus flavus isolated from maize seeds of different agroclimatic niches of India. Indian Phytopathology. 2020 Jun;73(2):219-36. Citation:2
  55. Gowda K, Swarup HA, Nagarakere SC, Rangappa S, Kanchugarkoppal RS, Kempegowda M. Structural studies of 2, 5-disubstituted 1, 3, 4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking. Synthetic Communications. 2020 May 18;50(10):1528-44. Citation:10
  56. Kumar V, Keshavayya J, Matada MN, Srinivasa SM, Rangappa S*. Synthesis, Characterization and Biological Potency of Butyl‐Pyridone Based Azo Dyes. Chemistry Select. 2020 May 14;5(18):5460-4. Citation:6
  57. Mohan CD, Rangappa S, Preetham HD, Nayaka SC, Gupta VK, Basappa S, Sethi G, Rangappa KS. Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. In Seminars in cancer biology. 2022 May 1 (80)157-182. Citation:86
  58. Somu C, Mohan CD, Ambekar S, Rangappa S, Baburajeev CP, Sukhorukov A, Mishra S, Shanmugam MK, Chinnathambi A, Alahmadi TA, Alharbi SA.Identification of a novel 1, 2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells. Biotechnology reports. 2020 Mar 1;25:e00438. Citation:9
  59. Anil SM, Rajeev N, Kiran KR, Swaroop TR, Mallesha N, Shobith R, Sadashiva MP. Multi-pharmacophore Approach to Bio-therapeutics: Piperazine Bridged Pseudo-peptidic Urea/Thiourea Derivatives as Anti-oxidant Agents. International Journal of Peptide Research and Therapeutics. 2020 Mar;26(1):151-8. Citation:3
  60. Somu C, Mohan CD, Ambekar S, Rangappa S, Baburajeev CP, Sukhorukov A, Mishra S, Shanmugam MK, Chinnathambi A, Alahmadi TA, Alharbi SA. Identification of a novel 1, 2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells. Biotechnology reports. 2020 Mar 1;25:e00438. Citation:9
  61. Kotian SY, Mohan CD, Merlo AA, Rangappa S, Nayak SC, Rai KL, Rangappa KS. Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications. Journal of Molecular Liquids. 2020 Jan 1;297:111686. Citation:39
  62. Lee JH, Mohan CD, Basappa S, Rangappa S, Chinnathambi A, Alahmadi TA, Alharbi SA, Kumar AP, Sethi G, Ahn KS, Rangappa KS.The IκB kinase inhibitor ACHP targets the STAT3 signaling pathway in human non-small cell lung carcinoma cells. Biomolecules. 2019 Dec 13;9(12):875. Citation:52
  63. Lee JH, Rangappa S, Mohan CD, Sethi G, Lin ZX, Rangappa KS, Ahn KS.Brusatol, a Nrf2 inhibitor targets STAT3 signaling cascade in head and neck squamous cell carcinoma. Biomolecules. 2019 Sep 30;9(10):550. Citation:59
  64. Keerthy HK, Mohan S, Bharathkumar H, Rangappa S, Svensson F, Bender A, Mohan CD, Rangappa KS, Bhatnagar R. Triazole‐Pyridine Dicarbonitrile Targets Phosphodiesterase 4 to Induce Cytotoxicity in Lung Carcinoma Cells. Chemistry & Biodiversity. 2019 Sep;16(9):e1900234. Citation:8
  65. Swarup HA, Chaithra N, Sandhya NC, Rangappa S, Mantelingu K, Rangappa KS.Innovative approach for the synthesis of N-substituted amides from nitriles and alcohols using propylphosphonic anhydride (T3P®) under solvent-free conditions. Synthetic Communications. 2019 Aug 18;49(16):2106-16. Citation:13
  66. Dukanya D, Swaroop TR, Rangappa S, Rangappa KS, Basappa B. Cyclization of Activated Methylene Isocyanides with Methyl N (N), N′-Di (tri) substituted Carbamimidothioate: A Novel Entry for the Synthesis of N, 1-Aryl-4-tosyl/ethoxycarbonyl-1H-imidazol-5-amines. SynOpen. 2019 Jul;3(03):71-6. Citation:4
  67. Lakshmeesha TR, Kalagatur NK, Mudili V, Mohan CD, Rangappa S, Prasad BD, Ashwini BS, Hashem A, Alqarawi AA, Malik JA, Abd_Allah EF.Biofabrication of zinc oxide nanoparticles with Syzygium aromaticum flower buds extract and finding its novel application in controlling the growth and mycotoxins of Fusarium graminearum. Frontiers in microbiology. 2019 Jun 12;10:1244. Citation:50
  68. Baburajeev CP, Mohan CD, Pandey V, Rangappa S, Shivalingegowda N, Kalash L, Devaraja S, Bender A, Lobie PE, Rangappa KS.Synthesis of CC, CN coupled novel substituted dibutyl benzothiazepinone derivatives and evaluation of their thrombin inhibitory activity. Bioorganic Chemistry. 2019 Jun 1;87:142-54. Citation:4
  69. Mohan CD, Hari S, Preetham HD, Rangappa S, Barash U, Ilan N, Nayak SC, Gupta VK, Vlodavsky I, Rangappa KS. Targeting heparanase in cancer: inhibition by synthetic, chemically modified, and natural compounds. Iscience. 2019 May 31;15:360-90. Citation:61
  70. Mohan S, Rangappa S, Anilkumar NC, Fuchs JE, Bender A, Rangappa KS, Bhatnagar R. Sulfated Ceria Catalyzed Synthesis of Imidazopyridines and Their Implementation as DNA Minor Groove Binders. Chemistry & Biodiversity. 2019 May;16(5):e1800435. Citation:4
  71. Swarup HA, Sandhya NC, Rangappa S, Mantelingu K, Rangappa KS. Efficient One‐Pot Synthesis of 3, 5‐Disubstituted 1, 3, 4‐Thiadiazole from Dithioesters under Mild Condition. Chemistry Select. 2019 Apr 24;4(15):4611-4. Citation:5
  72. Totiger TM, Srinivasan S, Jala VR, Lamichhane P, Dosch AR, Gaidarski AA, Joshi C, Rangappa S, Castellanos J, Vemula PK, Chen X. Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer Targeting PI3K/AKT/mTOR Pathway in Pancreatic Cancer. Molecular cancer therapeutics. 2019 Feb 1;18(2):301-11. Citation: 74
  73. Anil SM, Shobith R, Kiran KR, Swaroop TR, Mallesha N, Sadashiva MP. Facile synthesis of 1, 4-benzodiazepine-2, 5-diones and quinazolinones from amino acids as anti-tubercular agents. New Journal of Chemistry. 2019;43(1):182-7. Citation:26
  74. Gebrehiwot AG, Melka DS, Kassaye YM, Rehan IF, Rangappa S, Hinou H, Kamiyama T, Nishimura SI. Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers. PLoS One. 2018 Dec 28;13(12):e0209515. Citation: 43
  75. Ananda H, Sharath Kumar KS, Sudhanva MS, Rangappa S, Rangappa KS. A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression. Molecular and Cellular Biochemistry. 2018 Dec 449(1):137-44. Citation:23
  76. Mohan CD, Bharathkumar H, Rangappa S, Shanmugam MK, Chinnathambi A, Alharbi SA, Alahmadi TA, Bhattacharjee A, Lobie PE, Deivasigamani A, Hui KM. N-substituted pyrido-1, 4-oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-κB signaling pathway. Frontiers in pharmacology. 2018 Nov 5;9:1125 Citation : 33
  77. Pandey V, Wang B, Mohan CD, Raquib AR, Rangappa S, Srinivasa V, Fuchs JE, Girish KS, Zhu T, Bender A, Ma L. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proceedings of the National Academy of Sciences. 2018 Oct 30;115(44):E10505-14. Citation:
  78. Gilandoust M, Harsha KB, Mohan CD, Raquib AR, Rangappa S, Pandey V, Lobie PE, Rangappa KS. Synthesis, characterization and cytotoxicity studies of 1, 2, 3-triazoles and 1, 2, 4-triazolo [1, 5-a] pyrimidines in human breast cancer cells. Bioorganic & medicinal chemistry letters. 2018 Jul 15;28(13):2314-9. Citation:48
  79. Harsha KB, Rangappa S, Preetham HD, Swaroop TR, Gilandoust M, Rakesh KS, Rangappa KS. An Easy and Efficient Method for the Synthesis of Quinoxalines Using Recyclable and Heterogeneous Nanomagnetic‐Supported Acid Catalyst under Solvent‐Free Condition. Chemistry Select. 2018 May 15;3(18):5228-32. Citation: 23
  80. Uzma F, Mohan CD, Hashem A, Konappa NM, Rangappa S, Kamath PV, Singh BP, Mudili V, Gupta VK, Siddaiah CN, Chowdappa S. Endophytic fungi—alternative sources of cytotoxic compounds: a review. Frontiers in pharmacology. 2018 Apr 26;9:309. Citation:168
  81. Mohan CD, Anilkumar NC, Rangappa S, Shanmugam MK, Mishra S, Chinnathambi A, Alharbi SA, Bhattacharjee A, Sethi G, Kumar AP, Rangappa KS. Novel 1, 3, 4-oxadiazole induces anticancer activity by targeting NF-κB in hepatocellular carcinoma cells. Frontiers in oncology. 2018 Mar 19;8:42. Citation:65
  82. Ambekar SP, Mohan CD, Shirahatti A, Kumar MK, Rangappa S, Mohan S, Kotresh O, Rangappa KS. Synthesis of coumarin-benzotriazole hybrids and evaluation of their anti-tubercular activity. Letters in Organic Chemistry. 2018 Jan 1;15(1):23-31. Citation:17
  83. Baburajeev CP, Mohan CD, Rangappa S, Mason DJ, Fuchs JE, Bender A, Barash U, Vlodavsky I, Rangappa KS. Identification of novel class of triazolo-thiadiazoles as potent inhibitors of human heparanase and their anticancer activity. BMC cancer. 2017 Dec;17(1):1-4. Citation:44
  84. Nirvanappa AC, Mohan CD, Rangappa S, Ananda H, Sukhorukov AY, Shanmugam MK, Sundaram MS, Nayaka SC, Girish KS, Chinnathambi A, Zayed ME. Novel synthetic oxazines target NF-κB in colon cancer in vitro and inflammatory bowel disease in vivo. PLoS One. 2016 Sep 29;11(9):e0163209. Citation:42
  85. Siddaiah CN, Satyanarayana NR, Mudili V, Kumar Gupta V, Gurunathan S, Rangappa S, Huntrike SS, Srivastava RK. Elicitation of resistance and associated defense responses in Trichoderma hamatum induced protection against pearl millet downy mildew pathogen. Scientific Reports. 2017 Mar 21;7(1):1-8. Citation:93
  86. Sebastian A, Pandey V, Mohan CD, Chia YT, Rangappa S, Mathai J, Baburajeev CP, Paricharak S, Mervin LH, Bulusu KC, Fuchs JE. Novel adamantanyl-based thiadiazolyl pyrazoles targeting EGFR in triple-negative breast cancer. ACS omega. 2016 Dec 28;1(6):1412-24. Citation: 37
  87. Nirvanappa AC, Mohan CD, Rangappa S, Ananda H, Sukhorukov AY, Shanmugam MK, Sundaram MS, Nayaka SC, Girish KS, Chinnathambi A, Zayed ME. Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo. Plos one. 2017 Apr 6;12(4):e0175659. Citation:42
  88. Sulaiman NB, Mohan CD, Basappa S, Pandey V, Rangappa S, Bharathkumar H, Kumar AP, Lobie PE, Rangappa KS. An azaspirane derivative suppresses growth and induces apoptosis of ER-positive and ER-negative breast cancer cells through the modulation of JAK2/STAT3 signaling pathway. International journal of oncology. 2016 Sep 1;49(3):1221-9. Citation:40
  89. Mohan CD, Srinivasa V, Rangappa S, Mervin L, Mohan S, Paricharak S, Baday S, Li F, Shanmugam MK, Chinnathambi A, Zayed ME. Trisubstituted-imidazoles induce apoptosis in human breast cancer cells by targeting the oncogenic PI3K/Akt/mTOR signaling pathway. PLoS One. 2016 Apr 20;11(4):e0153155. Citation:119
  90. Anusha S, Mohan CD, Ananda H, Baburajeev CP, Rangappa S, Mathai J, Fuchs JE, Li F, Shanmugam MK, Bender A, Sethi G.Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs. Bioorganic & medicinal chemistry letters. 2016 Feb 1;26(3):1056-60. Citation:41
  91. Baburajeev CP, Mohan CD, Patil GS, Rangappa S, Pandey V, Sebastian A, Fuchs JE, Bender A, Lobie PE, Rangappa KS. Nano-cuprous oxide catalyzed one-pot synthesis of a carbazole-based STAT3 inhibitor: A facile approach via intramolecular C–N bond formation reactions. RSC advances. 2016;6(43):36775-85. Citation:19
  92. Rangappa S, Artigas G, Miyoshi R, Yokoi Y, Hayakawa S, Garcia-Martin F, Hinou H, Nishimura SI. Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats.. 2016;7(6):1102-22. Citation: 35
  93. Anusha S, Cp B, Mohan CD, Mathai J, Rangappa S, Mohan S, Paricharak S, Mervin L, Fuchs JE, Bender A, Rangappa KS. A Nano-MgO and ionic liquid-catalyzed ‘green synthesis protocol for the development of adamantyl-imidazolo-thiadiazoles as anti-tuberculosis agents targeting sterol 14α-demethylase (CYP51). PloS one. 2015 Oct 15;10(10):e0139798. Citation:24
  94. Baburajeev CP, Dhananjaya Mohan C, Ananda H, Rangappa S, Fuchs JE, Jagadish S, Sivaraman Siveen K, Chinnathambi A, Ali Alharbi S, Zayed ME, Zhang J. Development of novel triazolo-thiadiazoles from heterogeneous “green” catalysis as protein tyrosine phosphatase 1B inhibitors. Scientific reports. 2015 Sep 21;5(1):1-1. Citation:39
  95. Ashwini N, Garg M, Mohan CD, Fuchs JE, Rangappa S, Anusha S, Swaroop TR, Rakesh KS, Kanojia D, Madan V, Bender A. Synthesis of 1, 2-benzisoxazole tethered 1, 2, 3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation. Bioorganic & medicinal chemistry. 2015 Sep 15;23(18):6157-65. Citation:92
  96. Srinivas V, Mohan CD, Baburajeev CP, Rangappa S, Jagadish S, Fuchs JE, Sukhorukov AY, Mason DJ, Kumar KS, Madegowda M, Bender A. Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2. Bioorganic & Medicinal Chemistry Letters. 2015 Aug 1;25(15):2931-6. Citation:35
  97. Anilkumar NC, Sundaram MS, Mohan CD, Rangappa S, Bulusu KC, Fuchs JE, Girish KS, Bender A, Rangappa KS. A one pot synthesis of novel bioactive tri-substitute-condensed-imidazopyridines that targets snake venom phospholipase A2. PLoS One. 2015 Jul 21;10(7):e0131896. Citation:28
  98. Bharathkumar H, Mohan CD, Ananda H, Fuchs JE, Li F, Rangappa S, Surender M, Bulusu KC, Girish KS, Sethi G, Bender A. Microwave-assisted synthesis, characterization and cytotoxic studies of novel estrogen receptor α ligands towards human breast cancer cells. Bioorganic & medicinal chemistry letters. 2015 Apr 15;25(8):1804-7. Citation:39
  99. Baburajeev CP, Dhananjaya Mohan C, Ananda H, Rangappa S, Fuchs JE, Jagadish S, Sivaraman Siveen K, Chinnathambi A, Zayed ME, Zhang J, Li F. Development of novel triazolo-thiadiazoles from heterogeneous “green” catalysis as protein tyrosine phosphatase 1B inhibitors. Scientific reports. 2015 Sep 21;5(1):14195. Citation:39
  100. Keerthy HK, Vivek HK, Bharathkumar H, Rangappa S, Bulusu KC, Mervin LH, Fuchs JE, Priya BS, Bender A, Rangappa KS. MOLPRINT 2D-based identification and synthesis of novel chromene based small molecules that target PLA2: validation through chemo-and bioinformatics approaches. RSC advances. 2015;5(109):89797-808. Citation:8
  101. Bharathkumar H, Mohan CD, Rangappa S, Kang T, Keerthy HK, Fuchs JE, Kwon NH, Bender A, Kim S, Rangappa KS. Screening of quinoline, 1, 3-benzoxazine, and 1, 3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in-silico binding mode analysis. Organic & biomolecular chemistry. 2015;13(36):9381-7. Citation:44
  102. Mohan CD, Bharathkumar H, Bulusu KC, Pandey V, Rangappa S, Fuchs JE, Shanmugam MK, Dai X, Li F, Deivasigamani A, Hui KM. Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo. Journal of Biological Chemistry. 2014 Dec 5;289(49):34296-307. Citation: 156.
  103. Keerthy HK, Mohan CD, Siveen KS, Fuchs JE, Rangappa S, Sundaram MS, Li F, Girish KS, Sethi G, Bender A, Rangappa KS. Novel synthetic biscoumarins target tumor necrosis factor-α in hepatocellular carcinoma in vitro and in vivo. Journal of Biological Chemistry. 2014 Nov 14;289(46):31879-90. Citation:79
  104. Keerthy HK, Garg M, Mohan CD, Madan V, Kanojia D, Shobith R, Nanjundaswamy S, Mason DJ, Bender A, Rangappa KS, Koeffler HP. Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines. PloS one. 2014 Sep 30;9(9):e107118. Citation:62
  105. Bharathkumar H, Paricharak S, Dinesh KR, Siveen KS, Fuchs JE, Rangappa S, Mohan CD, Mohandas N, Kumar AP, Sethi G, Bender A. Synthesis, biological evaluation and in silico and in vitro mode-of-action analysis of novel dihydropyrimidones targeting PPAR-γ. RSC Advances. 2014;4(85):45143-6. Citation:35